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KMID : 0880220160540030243
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Journal of Microbiology
2016 Volume.54 No. 3 p.243 ~ p.253
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The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance
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Brown Neil A.
Goldman Gustavo H.
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Abstract
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Invasive aspergillosis has emerged as one of the most common life-threatening fungal disease of humans. The emergence of antifungal resistant pathogens represents a current and increasing threat to society. In turn, new strategies to combat fungal infection are urgently required. Fungal adaptations to stresses experienced within the human host are a prerequisite for the survival and virulence strategies of the pathogen. Here, we review the latest information on the signalling pathways in Aspergillus fumigatus that contribute to stress adaptations and virulence, while highlighting their potential as targets for the development of novel combinational antifungal therapies.
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KEYWORD
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aspergillosis, osmotic stress, oxidative stress, cell wall stress, hypoxia, heat shock, fungicide resistance
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